CAN YOU EXPLAIN HOW PHYSICAL EXERCISE AFFECTS THE BRAIN, PARTICULARLY IN RELATION TO ALZHEIMER’S DISEASE?
Exercise benefits body and brain function in so many ways, and these factors, blood flow, metabolism, mood, etc., are all interrelated. As such, it can be difficult to definitively identify any single factor that mediates the beneficial effects of exercise on Alzheimer’s disease. We know that exercise increases blood flow in the brain, it improves cognitive performance by, for example, increasing neuroplasticity (our brain’s ability to learn and adapt), and increase the levels of certain “neurotrophic” factors that enhance brain function and neuroplasticity. Studies have also suggested that exercise is associated with reduced levels of some of the key disease-related markers of Alzheimer’s disease, such as amyloid beta or neurofibrillary tangles, perhaps through the anti-inflammatory benefits of exercise.
IS THERE A SPECIFIC TYPE OR INTENSITY OF EXERCISE THAT’S BEEN SHOWN TO BE MORE EFFECTIVE IN SLOWING COGNITIVE DECLINE?
Evidence points most strongly to cognitive benefits of regular, at least moderate intensity, aerobic exercise. What constitutes “moderate intensity” depends on age and physical factors but typically includes exercise that results in moderate increases to heart rate and breathing. Importantly, any of these exercise regimens has to synergize with good diet and sleep habits to be maximally beneficial.
HOW EARLY IN LIFE SHOULD SOMEONE BEGIN EXERCISING TO GAIN PROTECTIVE BENEFITS AGAINST ALZHEIMER’S?
The greatest effects of exercise can be seen the earlier it is started and the longer period of time that it is maintained. Several impactful behavioral risk factors for Alzheimer’s disease are most prominent in midlife, for example obesity, hypertension, and sedentary lifestyle. Counteracting these midlife trends with regular exercise can have outsized and cumulative effects on protection against Alzheimer’s. Furthermore, the earliest Alzheimer’s related brain changes likely begin happening decades before the onset of clinical Alzheimer’s disease—increasing physical activity during this period may have a significant protective influence against Alzheimer’s. However, it is important to note that exercise at any age can have positive benefits; it is never too late to start.
Check out the entire Wellness Feature HERE
The post Exercise, Brain Health, and Alzheimer’s: Insights from UC Irvine Research appeared first on Orange Coast.